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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IRF3
All Species:
12.73
Human Site:
S385
Identified Species:
31.11
UniProt:
Q14653
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14653
NP_001562.1
427
47219
S385
M
A
R
V
G
G
A
S
S
L
E
N
T
V
D
Chimpanzee
Pan troglodytes
XP_001157487
217
24686
L177
R
V
G
G
A
S
S
L
E
N
T
V
D
L
H
Rhesus Macaque
Macaca mulatta
NP_001129269
422
46745
S380
I
A
R
V
G
G
A
S
S
L
E
N
T
V
D
Dog
Lupus familis
XP_533616
383
42701
S341
M
A
R
L
E
G
A
S
S
L
E
N
T
V
D
Cat
Felis silvestris
Mouse
Mus musculus
P70671
419
46834
S378
M
A
R
E
G
G
A
S
S
L
K
T
V
D
L
Rat
Rattus norvegicus
P23570
328
37046
I288
I
D
S
P
G
G
D
I
E
I
G
I
Q
R
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508806
462
52633
R407
M
F
S
G
D
F
T
R
S
F
D
S
G
S
V
Chicken
Gallus gallus
Q90871
425
49152
Q378
V
E
Q
L
C
V
R
Q
V
M
E
E
A
G
K
Frog
Xenopus laevis
NP_001079588
466
52659
Y426
K
L
L
H
D
M
S
Y
S
T
G
A
S
S
L
Zebra Danio
Brachydanio rerio
NP_001137376
426
47835
K377
G
E
K
W
P
D
P
K
M
K
P
W
E
K
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
50.3
94.3
67.2
N.A.
70.9
20.3
N.A.
28.1
26.2
32.8
24.5
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
50.5
96.9
74.4
N.A.
78.4
36.2
N.A.
44.3
40.2
53.2
41.9
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
0
93.3
86.6
N.A.
60
13.3
N.A.
13.3
6.6
6.6
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
13.3
100
93.3
N.A.
66.6
26.6
N.A.
26.6
33.3
20
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
40
0
0
10
0
40
0
0
0
0
10
10
0
0
% A
% Cys:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
20
10
10
0
0
0
10
0
10
10
30
% D
% Glu:
0
20
0
10
10
0
0
0
20
0
40
10
10
0
0
% E
% Phe:
0
10
0
0
0
10
0
0
0
10
0
0
0
0
0
% F
% Gly:
10
0
10
20
40
50
0
0
0
0
20
0
10
10
0
% G
% His:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
10
% H
% Ile:
20
0
0
0
0
0
0
10
0
10
0
10
0
0
0
% I
% Lys:
10
0
10
0
0
0
0
10
0
10
10
0
0
10
20
% K
% Leu:
0
10
10
20
0
0
0
10
0
40
0
0
0
10
20
% L
% Met:
40
0
0
0
0
10
0
0
10
10
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
10
0
30
0
0
0
% N
% Pro:
0
0
0
10
10
0
10
0
0
0
10
0
0
0
0
% P
% Gln:
0
0
10
0
0
0
0
10
0
0
0
0
10
0
0
% Q
% Arg:
10
0
40
0
0
0
10
10
0
0
0
0
0
10
0
% R
% Ser:
0
0
20
0
0
10
20
40
60
0
0
10
10
20
0
% S
% Thr:
0
0
0
0
0
0
10
0
0
10
10
10
30
0
0
% T
% Val:
10
10
0
20
0
10
0
0
10
0
0
10
10
30
20
% V
% Trp:
0
0
0
10
0
0
0
0
0
0
0
10
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _